Synthesis and lectin binding ability of glycosamino acid-calixarenes exposing GlcNAc clusters

被引：67

作者：

Consoli, GML ^{[1
]}

Cunsolo, F ^{[1
]}

Geraci, C ^{[1
]}

Sgarlata, V ^{[1
]}

机构：

[1] CNR, Sez Catania, Ist Chim Biomol, Via Santuario 110, I-95028 Valverde, CT, Italy

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 23期

关键词：

D O I：

10.1021/ol0485767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel calix[4 or 8]arene-based glycoconjugates exposing terminal N-acetyl-D-glucosamine clusters have been synthesized using amino acid-calixarenes as building blocks. The obtained glycosamino acid-calixarenes 9b-14b have lectin-binding ability and amplified inhibitory effects on erythrocyte agglutination induced by wheat germ (Triticum vulgaris) agglutinin (WGA). The inhibitory ability is dependent on the presence of the spacer and on the shape and rigidity of the calixarene skeleton.

引用

页码：4163 / 4166

页数：4

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