[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1

被引：21

作者：

Baraldi, PG ^{[1
]}

Cacciari, B

Guiotto, A

Romagnoli, R

Spalluto, G

Leoni, A

Bianchi, N

Feriotto, G

Rutigliano, C

Mischiati, C

Gambari, R

机构：

[1] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy

[2] Univ Ferrara, Dipartmento Biochim & Biol Mol, I-44100 Ferrara, Italy

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 08期

关键词：

D O I：

10.1080/15257770008033045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Spl were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.

引用

页码：1219 / 1229

页数：11

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