Allometric cascade: a model for resolving body mass effects on metabolism

Expanding upon a preliminary communication (Nature 417 (2002) 166), we here further develop a 'multiple-causes model' of allometry, where the exponent b is the sum of the influences of multiple contributors to control. The relative strength of each contributor, with its own characteristic value of b(i), is determined by c(i), the control contribution or control coefficient. A more realistic equation for the scaling of metabolism with body size thus can be written as BMR=MR(0)Sigmac(i)(M/M-0)(bi), where MR0 is the 'characteristic metabolic rate' of an animal with a 'characteristic body mass', M-0. With M-0 of 1 unit mass (usually kg), MR0 takes the place of the value a, found in the standard scaling equation, bi is the scaling exponent of the process i, and c(i) is its control contribution to overall flux, or the control coefficient of the process i. One can think of this as an allometric cascade, with the b exponent for overall energy metabolism being determined by the b(i) and c(i) values for key steps in the complex pathways of energy demand and energy supply. Key intrinsic factors (such as neural and endocrine processes) or ecological extrinsic factors are considered to act through this system in affecting allometric scaling of energy turnover. Applying this model to maximum vs. BMR data for the first time explains the differing scaling behaviour of these two biological states in mammals, both in the absence and presence of intrinsic regulators such as thyroid hormones (for BMR) and catecholamines (for maximum metabolic rate). (C) 2002 Elsevier Science Inc. All rights reserved.