Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes

被引：1017

作者：

Kansy, M ^{[1
]}

Senner, F ^{[1
]}

Gubernator, K ^{[1
]}

机构：

[1] F Hoffmann La Roche & Co Ltd, Pharmaceut Res, CH-4070 Basel, Switzerland

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 07期

关键词：

D O I：

10.1021/jm970530e

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1007 / 1010

页数：4

共 41 条

[1] PASSIVE DIFFUSION OF WEAK ORGANIC ELECTROLYTES ACROSS CACO-2 CELL MONOLAYERS - UNCOUPLING THE CONTRIBUTIONS OF HYDRODYNAMIC, TRANSCELLULAR, AND PARACELLULAR BARRIERS
ADSON, A
BURTON, PS
RAUB, TJ
BARSUHN, CL
AUDUS, KL
HO, NFH
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1995, 84 (10) : 1197 - 1204
[2] CORRELATION BETWEEN ORAL-DRUG ABSORPTION IN HUMANS AND APPARENT DRUG PERMEABILITY COEFFICIENTS IN HUMAN INTESTINAL EPITHELIAL (CACO-2) CELLS
ARTURSSON, P
KARLSSON, J
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (03) : 880 - 885
[3] PARTITIONING OF IONIZING MOLECULES BETWEEN AQUEOUS BUFFERS AND PHOSPHOLIPID-VESICLES
AUSTIN, RP
DAVIS, AM
MANNERS, CN
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1995, 84 (10) : 1180 - 1183
[4] ELECTRICAL CAPACITY OF BLACK LIPID FILMS AND OF LIPID BILAYERS MADE FROM MONOLAYERS
BENZ, R
FROHLICH, O
LAUGER, P
MONTAL, M
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 394 (03) : 323 - 334
[5] RECONSTITUTION OF BACTERIORHODOPSIN IN A MILLIPORE FILTER SYSTEM
BLOK, MC
HELLINGWERF, KJ
VANDAM, K
[J]. FEBS LETTERS, 1977, 76 (01) : 45 - 50
[6] CAMENISH GP, 1996, THESIS SWITZERLAND
[7] WATER PERMEABILITY OF THIN LIPID MEMBRANES
CASS, A
FINKELSTEIN, A
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 1967, 50 (6P1) : 1765 - +
[8] Chan OH, 1996, DRUG DISCOV TODAY, V1, P461
[9] CHENG YY, 1996, ADV DRUG DEL REV, V23, P229
[10] In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system
Chong, SH
Dando, SA
Soucek, KM
Morrison, RA
[J]. PHARMACEUTICAL RESEARCH, 1996, 13 (01) : 120 - 123

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