The third-stage larva (L3) of Brugia:: its role in immune modulation and protective immunity

被引：30

作者：

Devaney, E ^{[1
]}

Osborne, J ^{[1
]}

机构：

[1] Univ Glasgow, Dept Vet Parasitol, Glasgow G61 1QH, Lanark, Scotland

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 11期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

L3; Brugia; T lymphocyte; double-negative; antigen-presenting cell; IL-4; IL-10;

D O I：

10.1016/S1286-4579(00)01290-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this review, we focus on the role of the L3 (third-stage larva) of lymphatic filarial nematodes in immunomodulation and in the development of protective immunity. Studies in the mouse models of Brugia have been fundamental to our understanding of the mechanisms by which infection with L3 results in Th2 responses and the active suppression of Th1 responses. The relevance of these phenomena to the human infection is discussed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1363 / 1371

页数：9

共 53 条

[1] APC from mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production
Allen, JE
Lawrence, RA
Maizels, RM
[J]. INTERNATIONAL IMMUNOLOGY, 1996, 8 (01) : 143 - 151
[2] ALLEN JE, 1909, IMMUNOL TODAY, V8, P387
[3] THE ROLE OF CD4 CELLS IN PROTECTIVE IMMUNITY TO BRUGIA-PAHANGI
BANCROFT, AJ
GRENCIS, RK
ELSE, KJ
DEVANEY, E
[J]. PARASITE IMMUNOLOGY, 1994, 16 (07) : 385 - 387
[4] BANCROFT AJ, 1993, J IMMUNOL, V150, P1395
[5] RECOGNITION OF A LIPID ANTIGEN BY CD1-RESTRICTED ALPHA-BETA(+) T-CELLS
BEEKMAN, EM
PORCELLI, SA
MORITA, CT
BEHAR, SM
FURLONG, ST
BRENNER, MB
[J]. NATURE, 1994, 372 (6507) : 691 - 694
[6] CD1 - PRESENTING UNUSUAL ANTIGENS TO UNUSUAL T-LYMPHOCYTES
BENDELAC, A
[J]. SCIENCE, 1995, 269 (5221) : 185 - 186
[7] beta 2-microglobulin-dependent NK1.1(+) T cells are not essential for T helper cell 2 immune responses
Brown, DR
Fowell, DJ
Corry, DB
Wynn, TA
Moskowitz, NH
Cheever, AW
Locksley, RM
Reiner, SL
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (04) : 1295 - 1304
[8] Burdin N, 1999, EUR J IMMUNOL, V29, P2014, DOI 10.1002/(SICI)1521-4141(199906)29:06<2014::AID-IMMU2014>3.0.CO
[9] 2-G
[10] CARLOW C K S, 1987, P301

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