Long-Term Efficacy and Safety of Raltegravir Combined with Optimized Background Therapy in Treatment-Experienced Patients with Drug-Resistant HIV Infection: Week 96 Results of the BENCHMRK 1 and 2 Phase III Trials

被引：175

作者：

Steigbigel, Roy T. ^{[2
]}

Cooper, David A. ^{[7
]}

Teppler, Hedy ^{[1
]}

Eron, Joseph J. ^{[5
]}

Gatell, Jose M. ^{[8
]}

Kumar, Princy N. ^{[4
]}

Rockstroh, Jurgen K. ^{[10
]}

Schechter, Mauro ^{[11
]}

Katlama, Christine ^{[12
]}

Markowitz, Martin ^{[3
]}

Yeni, Patrick ^{[13
]}

Loutfy, Mona R. ^{[14
]}

Lazzarin, Adriano ^{[15
]}

Lennox, Jeffrey L. ^{[6
]}

Clotet, Bonaventura ^{[9
]}

Zhao, Jing ^{[1
]}

Wan, Hong ^{[1
]}

Rhodes, Rand R. ^{[1
]}

Strohmaier, Kim M. ^{[1
]}

Barnard, Richard J. ^{[1
]}

Isaacs, Robin D. ^{[1
]}

Nguyen, Bach-Yen T. ^{[1
]}

机构：

[1] Merck Res Labs, N Wales, PA 19454 USA

[2] SUNY Stony Brook, Stony Brook, NY 11794 USA

[3] Rockefeller Univ, Aaron Diamond Res Ctr, New York, NY 10021 USA

[4] Georgetown Univ, Med Ctr, Washington, DC 20007 USA

[5] Univ N Carolina, Chapel Hill, NC USA

[6] Emory Univ, Sch Med, Atlanta, GA USA

[7] Univ New S Wales, Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW, Australia

[8] Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain

[9] UAB, Fdn Irsicaixa, Hosp Germans Trias & Pujol, Barcelona, Spain

[10] Univ Bonn, Dept Med, D-5300 Bonn, Germany

[11] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil

[12] Univ Paris 06, Hosp Pitie Salpetriere, Paris, France

[13] Hosp Bichat Claude Bernard, Paris, France

[14] Univ Toronto, Toronto, ON, Canada

[15] Ist Sci San Raffaele, I-20132 Milan, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2010年 / 50卷 / 04期

关键词：

SUBGROUP;

D O I：

10.1086/650002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BENCHMRK-1 and -2 are ongoing double-blind phase III studies of raltegravir in patients experiencing failure of antiretroviral therapy with triple-class drug-resistant human immunodeficiency virus infection. At week 96 (combined data), raltegravir (400 mg twice daily) plus optimized background therapy was generally well tolerated, with superior and durable antiretroviral and immunological efficacy, compared with optimized background therapy alone.

引用

页码：605 / 612

页数：8

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