Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy

被引：77

作者：

Munakata, M ^{[1
]}

Kato, R

Yokoyama, H

Haginoya, K

Tanaka, Y

Kayaba, J

Kato, T

Takayanagi, R

Endo, H

Hasegawa, R

Ejima, Y

Hoshi, K

Iinuma, K

机构：

[1] Tohoku Univ, Sch Med, Dept Pediat, Sendai, Miyagi 980, Japan

[2] Tohoku Univ, Sch Med, Dept Anesthesia, Sendai, Miyagi 980, Japan

[3] Sendai Res Cross Hosp, Dept Pediat, Sendai, Miyagi, Japan

[4] Tohoku Rosai Hosp, Dept Pediat, Sendai, Miyagi, Japan

来源：

BRAIN & DEVELOPMENT | 2000年 / 22卷 / 06期

关键词：

hypothermia; corticosteroid; ulinastatin; influenza A virus;

D O I：

10.1016/S0387-7604(00)00169-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two children with influenza A-related encephalopathy were treated with a combination of mild hypothermia (deep body temperature of the forehead: 35 degreesC) and anticytokine agents thigh-dose methylprednisolone and ulinastatin), while receiving amantadine. One of the cases exhibited acute necrotizing encephalopathy on computed tomography (CT). Although no severe complications occurred, correctable hypokalemia and hyperglycemia occurred in both cases. Both patients recovered without any neurological sequelae. Our therapeutic protocol appears to be effective for managing influenza A-related encephalopathy. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：373 / 377

页数：5

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