The role of thrombospondin-1 in human disease

被引：96

作者：

Esemuede, N

Lee, T

Pierre-Paul, D

Sumpio, BE

Gahtan, V

机构：

[1] Yale Univ, Sch Med, New Haven, CT USA

[2] VA Connecticut Healthcare Syst, West Haven, CT USA

来源：

JOURNAL OF SURGICAL RESEARCH | 2004年 / 122卷 / 01期

关键词：

D O I：

10.1016/j.jss.2004.05.015

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein secreted by many cell types. It is a component of the extracellular matrix during active and subacute processes. Due to TSP-1's ability to interact with a variety of matrix proteins and cell-surface receptors, controversy exists about its conflicting functions. In this review, we will discuss the role of TSP-1 in human disease. (C) 2004 Elsevier Inc. All rights reserved.

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页码：135 / 142

页数：8

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