The unfolded protein response and integrated stress response to anoxia

被引：51

作者：

Rzymski, Tomasz ^{[1
]}

Harris, Adrian L. ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Canc Res UK, Weatherall Inst Mol Med, Oxford OX3 9DS, England

来源：

CLINICAL CANCER RESEARCH | 2007年 / 13卷 / 09期

关键词：

D O I：

10.1158/1078-0432.CCR-06-2126

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The lack of oxygen delivery to tumor cells has profound consequences for tumor growth and correlates with poor prognosis. Some tumors contain regions of very severe hypoxia called anoxia, which constitutes a functionally different state to hypoxia. In response to anoxia, mammalian cells induce coordinated cytoprotective programs that are critical for tumor survival: the unfolded protein response and integrated stress response. Therefore, targeting additional components of anoxic pathways, besides the hypoxia-inducible response, may be effective for future anticancer therapies.

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页码：2537 / 2540

页数：4

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