Neurokinin-1 receptor interacts with PrP106-126-induced dendritic cell migration and maturation

被引：13

作者：

Kaneider, NC

Kaser, A

Dunzendorfer, S

Tilg, H

Patsch, JR

Wiedermann, CJ

机构：

[1] Med Univ Innsbruck, Dept Internal Med, Div Gen Internal Med, A-6020 Innsbruck, Austria

[2] Med Univ Innsbruck, Dept Internal Med, Div Gastroenterol, A-6020 Innsbruck, Austria

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 158卷 / 1-2期

关键词：

prion; neuropeptides; neuroguidance; dendritic cells; NK-1; receptor;

D O I：

10.1016/j.jneuroim.2004.09.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Circulating monocytic cells may mediate neuroinvasion in transmissible spongiform encephalopathies by transporting prion protein (PrP) from sites of entry to the nervous system. Factors regulating rnonocyte-derived dendritic cell (DC) functions in neuronal tissue include neurogenic mediators, but their interactions with prion-infected DCs are unknown. Here, we report that neuropeptides regulate the interaction of DCs exposed to PrP106-126. Inhibition of neurokinin-1-receptors activation with neurokinin-1-receptor antagonist or antibody attenuates substance P-induced enhancement of DC migration induced by PrP106-126 and prion-protein-induced DC maturation. Other neuropeptides arrest chemotaxis. Data support a priming role of the neuropeptide substance P in PrP106-126-induced migration of DCs involving neurokinin-1-receptors. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：153 / 158

页数：6

共 30 条

[1]

Aucouturier P, 2002, J LEUKOCYTE BIOL, V72, P1075

[2] Activation by prion peptide PrP106-126 induces a NF-κB-driven proinflammatory response in human monocyte-derived dendritic cells [J].