Vitamin D in the treatment of pulmonary tuberculosis

被引：167

作者：

Martineau, Adrian R.

Honecker, Friedemann U.

Wilkinson, Robert J.

Griffiths, Christopher J.

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Ctr Hlth Sci, Inst Hlth Sci Educ, London E1 2AT, England

[2] Univ London Imperial Coll Sci Technol & Med, Wellcome Trust Ctr Res Clin Trop Med, Div Med, Wright Fleming Inst, London W2 1PG, England

[3] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, ZA-7925 Observatory, South Africa

[4] Univ Hamburg, Med Ctr, Dept Internal Med, D-20246 Hamburg, Germany

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2007年 / 103卷 / 3-5期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

vitamin D; tuberculosis; paradoxical reaction; hypercalcemia;

D O I：

10.1016/j.jsbmb.2006.12.052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vitamin D was used to treat tuberculosis in the pre-antibiotic era. New insights into the immunomodulatory properties of 10,25-dihydroxyvitamin D have rekindled interest in vitamin D as an adjunct to antituberculous therapy. We describe the historical use of vitamin D in tuberculosis treatment: discuss the mechanisms by which it may modulate host response to infection with Mycobacterium tuberculosis; and review three clinical trials and ten case series in which vitamin D has been used in the treatment of pulmonary tuberculosis. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：793 / 798

页数：6

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