Diabetes, obesity, and the brain

被引：602

作者：

Schwartz, MW ^{[1
]}

Porte, D

机构：

[1] Univ Washington, Div Metab Endocrinol & Nutr, Seattle, WA 98110 USA

[2] Harborview Med Ctr, Seattle, WA 98110 USA

[3] Univ Calif San Diego, Div Endocrinol Diabet & Metab, San Diego, CA 92161 USA

[4] VA San Diego Hlth Care Syst, Div Endocrinol Diabet & Metab, San Diego, CA 92161 USA

来源：

SCIENCE | 2005年 / 307卷 / 5708期

关键词：

D O I：

10.1126/science.1104344

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent evidence suggests a key role for the brain in the control of both body fat content and glucose metabolism. Neuronal systems that regulate energy intake, energy expenditure, and endogenous glucose production sense and respond to input from hormonal and nutrient-related signals that convey information regarding both body energy stores and current energy availability. In response to this input, adaptive changes occur that promote energy homeostasis and the maintenance of blood glucose levels in the normal range. Defects in this control system are implicated in the link between obesity and type 2 diabetes.

引用

页码：375 / 379

页数：5

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