Ricin poisoning and forensic toxicology

被引:61
作者
Musshoff, Frank [1 ]
Madea, Burkhard [1 ]
机构
[1] Univ Bonn, Inst Forens Med, D-53111 Bonn, Germany
关键词
ricin; immunoassay; chromatography; toxicology; forensic; Markov; umbrella; warfare; GALACTOSE-BINDING ABILITY; CAPILLARY-ELECTROPHORESIS; MUTATIONAL ANALYSIS; PROTEIN-SYNTHESIS; LECTINS ABRIN; TOXICITY; IDENTIFICATION; IMMUNOASSAY; QUANTIFICATION; ANTIBODIES;
D O I
10.1002/dta.27
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Ricin is one of the most fascinating poisons due to its high toxicity: as little as 500 mu g can kill an adult. It gained fame by its use in the so-called 'umbrella murder' to kill the Bulgarian dissident Georgi Markov in 1978. Ricin also became known as a potential bio-terror agent to which people could be exposed through the air, food, or water. The origin, biochemistry, toxicity, and analytical procedures for the determination of ricin are summarized. The homicide of Markov is described as well as recent cases of criminal ricin use. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:184 / 191
页数:8
相关论文
共 84 条
[1]   Improved fluoroimmunoassays using the dye Alexa Fluor 647 with the RAPTOR, a fiber optic biosensor [J].
Anderson, GP ;
Nerurkar, NL .
JOURNAL OF IMMUNOLOGICAL METHODS, 2002, 271 (1-2) :17-24
[2]   Ricin poisoning - A comprehensive review [J].
Audi, J ;
Belson, M ;
Patel, M ;
Schier, J ;
Osterloh, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (18) :2342-2351
[3]   RICIN - TOXIC PROTEIN OF CASTOR-OIL SEEDS [J].
BALINT, GA .
TOXICOLOGY, 1974, 2 (01) :77-102
[4]   Detection of functional ricin by immunoaffinity and liquid chromatography-tandem mass spectrometry [J].
Becher, F. ;
Duriez, E. ;
Volland, H. ;
Tabet, J. C. ;
Ezan, E. .
ANALYTICAL CHEMISTRY, 2007, 79 (02) :659-665
[5]  
BRADBERRY SM, 2003, TOXICOL REV, V22, P60
[6]   Evaluation of an in vitro bioassay for the detection of purified ricin and castor bean in beverages and liquid food matrices [J].
Brzezinski, Jennifer L. ;
Craft, David L. .
JOURNAL OF FOOD PROTECTION, 2007, 70 (10) :2377-2382
[7]  
CARTER RM, 1995, ANAL LETT, V28, P1379
[8]  
Centers for Disease Control and Prevention (CDC), 2003, MMWR Morb Mortal Wkly Rep, V52, P1129
[9]   CASTOR BEAN INTOXICATION [J].
CHALLONER, KR ;
MCCARRON, MM .
ANNALS OF EMERGENCY MEDICINE, 1990, 19 (10) :1177-1183
[10]  
*CNN, 2003, RIC WEAP