Hiyama reactions of activated and unactivated secondary alkyl halides catalyzed by a nickel/norephedrine complex

被引：128

作者：

Strotman, Neil A. ^{[1
]}

Sommer, Stefan ^{[1
]}

Fu, Gregory C. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 19期

关键词：

amino alcohols; cross-coupling; homogeneous catalysis; nickel; silicon;

D O I：

10.1002/anie.200700440

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) An active partner: Nickel in combination with an amino alcohol ligand (norephedrine) was found to provide the most versatile and efficient catalyst for Hiyama cross-coupling reactions of alkyl electrophiles that has been described to date. Unprecedented Hiyama reactions of activated secondary alkyl bromides were achieved, as were the first Hiyama couplings of (activated) alkyl chlorides (see scheme, X = Br, Cl; HMDS = 1,1,1,3,3,3-hexamethyldisilazane, DMA = N,N-dimethylacetamide). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3556 / 3558

页数：3

共 20 条

[1]

[Anonymous], METAL CATALYZED CROS

[2] Chiral 2,2′-bipyridines, 1,10-phenanthrolines, and 2,2′:6′,2"-terpyridines:: Syntheses and applications in asymmetric homogeneous catalysis [J].