Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

被引：595

作者：

Hogan, Patrick G. ^{[1
,2
]}

Lewis, Richard S. ^{[3
]}

Rao, Anjana ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA

[2] Childrens Hosp Boston, Program Cellular & Mol Med, Boston, MA 02115 USA

[3] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 | 2010年 / 28卷

关键词：

CRAC channels; store-operated calcium entry; T cell activation; primary immunodeficiencies; OPERATED CA2+ ENTRY; T-CELL-ACTIVATION; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; FAST CA2+-DEPENDENT INACTIVATION; STROMAL INTERACTION MOLECULE-1; CA2+-SELECTIVE ARC CHANNELS; BEARING DENDRITIC CELLS; NAADP MOBILIZES CALCIUM; STORE-INDEPENDENT MODES; TYROSINE KINASE SYK;

D O I：

10.1146/annurev.immunol.021908.132550

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective channels known as CRAC (calcium release-activated calcium) channels. CRAG channels are a very well-characterized example of store-operated Ca2+ channels, so designated because they open when the endoplasmic reticulum (ER) Ca2+ store becomes depleted. Physiologically, Ca2+ is released from the ER lumen into the cytoplasm when activated receptors couple to phospholipase C and trigger production of the second messenger inositol 1,4,5-trisphosphate (IP3). IP3 binds to IP3 receptors in the ER membrane and activates Ca2+ release. The proteins STIM and ORAI were discovered through limited and genome-wide RNAi screens, respectively, performed in Drosophila cells and focused on identifying modulators of store-operated Ca2+ entry. STIM1 and STIM2 sense the depletion of ER Ca2+ stores, whereas ORAI1 is a pore subunit of the CRAG channel. In this review, we discuss selected aspects of Ca2+ signaling in cells of the immune system, focusing on the roles of STIM and ORAI proteins in store-operated Ca2+ entry.

引用

页码：491 / 533

页数：43

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