The corticofugal system for hearing: Recent progress

被引:171
作者
Suga, N [1 ]
Gao, EQ [1 ]
Zhang, YF [1 ]
Ma, XF [1 ]
Olsen, JF [1 ]
机构
[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA
关键词
auditory system; descending system; learning and memory; plasticity; tonotopic map;
D O I
10.1073/pnas.97.22.11807
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Peripheral auditory neurons are tuned to single frequencies of sound. In the central auditory system, excitatory (or facilitatory) and inhibitory neural interactions take place at multiple levels and produce neurons with sharp level-tolerant frequency-tuning curves, neurons tuned to parameters other than frequency, cochleotopic (frequency) maps, which are different from the peripheral cochleotopic map, and computational maps. The mechanisms to create the response properties of these neurons have been considered to be solely caused by divergent and convergent projections of neurons in the ascending auditory system. The recent research on the corticofugal (descending) auditory system, however, indicates that the corticofugal system adjusts and improves auditory signal processing by modulating neural responses and maps. The corticofugal function consists of at least the following subfunctions. (i) Egocentric selection for short-term modulation of auditory signal processing according to auditory experience. Egocentric selection, based on focused positive feedback associated with widespread lateral inhibition, is mediated by the cortical neural net working together with the corticofugal system. (ii) Reorganization for long-term modulation of the processing of behaviorally relevant auditory signals. Reorganization is based on egocentric selection working together with nonauditory systems. (iii) Gain control based on overall excitatory. facilitatory, or inhibitory corticofugal modulation, Egocentric selection can be viewed as selective gain control. (iv) Shaping (or even creation) of response properties of neurons, Filter properties of neurons in the frequency, amplitude, time, and spatial domains can be sharpened by the corticofugal system. Sharpening of tuning is one of the functions of egocentric selection.
引用
收藏
页码:11807 / 11814
页数:8
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