Metallo-ROS in Alzheimer's disease:: Oxidation of neurotransmitters by CuII-β-amyloid and neuropathology of the disease

被引：46

作者：

da Silva, Giordano F. Z.

Ming, Li-June ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Univ S Florida, Inst Biomol Sci, Tampa, FL 33620 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 18期

关键词：

Alzheimer's disease; copper; oxidoreductases; peptides; redox chemistry;

D O I：

10.1002/anie.200604421

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A clear mind: The CuII-β-amyloid (Aβ) complex has been shown to exhibit enzyme-like metal-centered oxidative and hydroxylation catalyses. Metal-centered oxidation of various neurotransmitters by CuAβ under biomimetic conditions has verified the bio-relevance of the metal-centered catalyses and is expected to provide a chemical basis for the better understanding of the etiology of Alzheimer's disease. ROS = reactive oxygen species. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：3337 / 3341

页数：5

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