Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology

被引：180

作者：

Shiozaki, EN ^{[1
]}

Shi, YG ^{[1
]}

机构：

[1] Princeton Univ, Lewis Thomas Lab, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tibs.2004.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caspases are the central component of the apoptotic machinery that irreversibly commits a cell to die. Whereas all caspases are structurally similar, those involved in apoptosis can be categorized functionally as either initiator or effector caspases, which are activated by distinct mechanisms. The activated caspases are subject to inhibition by the inhibitor of apoptosis family of proteins. This inhibition can be removed by Smac/DIABLO during apoptosis. The underlying molecular mechanisms of caspase regulation are discussed in this article.

引用

页码：486 / 494

页数：9

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