Viewpoint -: How can drug discovery for psychiatric disorders be improved?

被引：164

作者：

Agid, Yves ^{[1
]}

Buzsaki, Gyoergvy ^{[1
]}

Diamond, David M. ^{[1
]}

Frackowiak, Richard ^{[1
]}

Giedd, Joy ^{[1
]}

Girault, Jean-Antoine ^{[1
]}

Grace, Anthony ^{[1
]}

Lambert, Jerry J. ^{[1
]}

Manji, Husseini ^{[1
]}

Mayberg, Helen ^{[1
]}

Popoli, Maurizio ^{[1
]}

Prochiantz, Alain ^{[1
]}

Richter-Levin, Gal ^{[1
]}

Somogyi, Peter ^{[1
]}

Spedding, Michael ^{[1
]}

Svenningsson, Per ^{[1
]}

Weinberger, Daniel ^{[1
]}

机构：

[1] IDRS, F-92150 Suresnes, France

来源：

NATURE REVIEWS DRUG DISCOVERY | 2007年 / 6卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrd2217

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability worldwide, and have a huge societal impact. However, despite the clear need for better therapies, and major advances in the understanding of the molecular basis of these disorders in recent years, efforts to discover and develop new drugs for neuropsychiatric disorders, particularly those that might revolutionize disease treatment, have been relatively unsuccessful. A multidisciplinary approach will be crucial in addressing this problem, and in the first Advances in Neuroscience for Medical Innovation symposium, experts in multiple areas of neuroscience considered key questions in the field, in particular those related to the importance of neuronal plasticity. The discussions were used as a basis to propose steps that can be taken to improve the effectiveness of drug discovery for psychiatric disorders.

引用

页码：189 / 201

页数：13

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