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Bovine papillomavirus and cancer

被引：99
作者：
Campo, MS
机构：
[1] Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Bearsden, Glasgow G61 1BD, Switchback Road
来源：
VETERINARY JOURNAL | 1997年 / 154卷 / 03期
基金：
英国医学研究理事会;
关键词：
papillomavirus; cancer; cell transformation; cofactors; vaccination;
D O I：
10.1016/S1090-0233(97)80019-6
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Bovine papillomavirus (BPV) induces papillomas of cutaneous or mucosal epithelia in cattle. The papillomas are benign tumours and generally regress, but occasionally persist and provide the focus for malignant transformation to squamous cell carcinoma, particularly in the presence of environmental cofactors. This has been experimentally demonstrated for BPV-2 and cancer of the urinary bladder, and BPV-4 and cancer of the upper alimentary canal in cattle feeding on bracken fern. In this review, several aspects of the biology of the virus are described including viral genome structure, regulation of transcription of the viral oncogenes, function of the viral oncoproteins, cooperation between virus and chemical cofactors in carcinogenesis, virus latency and prophylactic and therapeutic vaccination programmes.
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收藏
页码：175 / 188
页数：14
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