Subthalamic stimulation differentially modulates declarative and nondeclarative memory

被引：37

作者：

Hälbig, TD

Gruber, D

Kopp, UA

Scherer, P

Schneider, GH

Trottenberg, T

Arnold, G

Kupsch, A

机构：

[1] Charite Univ Med Berlin, Dept Neurol, D-13353 Berlin, Germany

[2] Charite Univ Med Berlin, Dept Neurosurg, D-13353 Berlin, Germany

[3] CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA

来源：

NEUROREPORT | 2004年 / 15卷 / 03期

关键词：

basal ganglia; declarative; high frequency deep brain stimulation; long-term memory; non-declarative; Parkinson's disease;

D O I：

10.1097/01.wnr.0000112223.63950.7c

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Declarative memory has been reported to rely on the medial temporal lobe system, whereas non-declarative memory depends on basal ganglia structures. We investigated the functional role of the subthalamic nucleus (STN), a structure closely connected with the basal ganglia for both types of memory. Via deep brain high frequency stimulation (DBS) we manipulated neural activity of the STN in humans. We found that DBS-STN differentially modulated memory performance: declarative memory was impaired, whereas non-declarative memory was improved in the presence of STN-DBS indicating a specific role of the STN in the activation of memory systems.

引用

页码：539 / 543

页数：5

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