Similar dynamics of G-protein coupled receptors molecules in response to antagonist binding

被引:5
作者
Järv, J [1 ]
Oras, A [1 ]
机构
[1] Univ Tartu, Inst Organ & Bioorgan Chem, EE-51014 Tartu, Estonia
关键词
G-protein coupled receptor; antagonist; kinetic mechanism; structure transition;
D O I
10.1016/j.neulet.2004.10.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In this communication we would like to draw attention on surprisingly similar transition of G-protein coupled receptors (GPCR) molecules, observed in these kinetic studies made with different receptors and their antagonists. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:150 / 152
页数:3
相关论文
共 16 条
[1]   An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors [J].
Baldwin, JM ;
Schertler, GFX ;
Unger, VM .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 272 (01) :144-164
[2]  
JARV J, 1979, J BIOL CHEM, V254, P5595
[3]  
JARV J, 1987, SYNAPTIC TRANSMITTER, P101
[4]  
JARV J, 1987, P ACAD SCI ESTONIAN, V36, P172
[5]   Activation of G-protein-coupled receptors: a common molecular mechanism [J].
Karnik, SS ;
Gogonea, C ;
Patil, S ;
Saad, Y ;
Takezako, T .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2003, 14 (09) :431-437
[6]  
KOIV AH, 1986, ORG REACTIVITY+, V23, P403
[7]   Kinetic evidence for isomerization of the dopamine receptor-raclopride complex [J].
Lepiku, M ;
Rinken, A ;
Jarv, J ;
Fuxe, K .
NEUROCHEMISTRY INTERNATIONAL, 1996, 28 (5-6) :591-595
[8]   Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions [J].
Madabushi, S ;
Gross, AK ;
Philippi, A ;
Meng, EC ;
Wensel, TG ;
Lichtarge, O .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (09) :8126-8132
[9]   Kinetics of [35S]dATPαS interaction with P2Y1 purinoceptor in rat brain membranes [J].
Oras, A ;
Järv, J .
NEUROSCIENCE LETTERS, 2004, 355 (1-2) :9-12
[10]   Kinetic analysis of [35S]dATPαS interaction with P2y1 nucleotide receptor [J].
Oras, A ;
Kilk, K ;
Kunapuli, S ;
Barnard, EA ;
Järv, J .
NEUROCHEMISTRY INTERNATIONAL, 2002, 40 (05) :381-386