Highly enantioselective copper-catalyzed substitution of allylic chlorides with diorganozincs

被引：67

作者：

Dübner, F ^{[1
]}

Knochel, P ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 48期

关键词：

copper; enantioselective allylation; zinc; asymmetric synthesis; ferrocene;

D O I：

10.1016/S0040-4039(00)01671-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new ferrocenyl ligand ii allows the performance of a highly enantioselective copper catalyzed S(N)2'-allylic substitution of allylic chlorides with diorganozincs, providing substituted products with enantiomeric excesses of up to 98%. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9233 / 9237

页数：5

共 19 条

[1]

Dübner F, 1999, ANGEW CHEM INT EDIT, V38, P379, DOI 10.1002/(SICI)1521-3773(19990201)38:3<379::AID-ANIE379>3.0.CO

[2]

2-Y

[3] Phosphinooxazolines - A new class of versatile, modular P,N-ligands for asymmetric catalysis [J].