Control of keratinocyte proliferation and differentiation by p63

被引：76

作者：

Truong, Amy B.

Khavari, Paul A.

机构：

[1] Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA

[2] Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA USA

来源：

CELL CYCLE | 2007年 / 6卷 / 03期

关键词：

epidermis; skin; differentiation; proliferation; p63; p53;

D O I：

10.4161/cc.6.3.3753

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The p53 family member p63 has been implicated in both the development and maintenance of stratified epithelial tissues, including the epidermis. Increasing data support p63 function in the regenerative capacity of basal keratinocytes by maintaining cell proliferation. Recent studies further suggest this regulation relies on inhibition of p53 activity. In addition, p63 appears to exert separate control over epidermal differentiation, which may involve control of such key signaling molecules as IKK alpha and Notch. While studies over the past decade have greatly expanded our knowledge of p63 function, much remains to be understood regarding how p63 regulates epidermal homeostasis. Future efforts to identify and validate direct p63 target genes as well as to understand the expression and function of individual p63 isoforms will be important to further define how p63 functions in the control of keratinocyte proliferation and differentiation.

引用

收藏

页码：295 / 299

页数：5

相关论文

共 61 条

[1] An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer [J].

Antonini, D ;

Rossi, B ;

Han, R ;

Minichiello, A ;

Di Palma, T ;

Corrado, M ;

Banfi, S ;

Zannini, M ;

Brissette, JL ;

Missero, C .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (08) :3308-3318

[2] Cloning and chromosomal mapping of the human p53-related KET gene to Chromosome 3q27 and its murine homolog Ket to mouse Chromosome 16 [J].

Augustin, M ;

Bamberger, C ;

Paul, D ;

Schmale, H .

MAMMALIAN GENOME, 1998, 9 (11) :899-902

[3] Zebrafish ΔNp63 is a direct target of bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm [J].

Bakkers, J ;

Hild, M ;

Kramer, C ;

Furutani-Seiki, M ;

Hammerschmidt, M .

DEVELOPMENTAL CELL, 2002, 2 (05) :617-627

[4] IGFBP-3 is a direct target of transcriptional regulation by ΔNp63α in squamous epithelium [J].

Barbieri, CE ;

Perez, CA ;

Johnson, KN ;

Ely, KA ;

Billheimer, D ;

Pietenpol, JA .

CANCER RESEARCH, 2005, 65 (06) :2314-2320

[5] T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects [J].

Beima, KM ;

Miazgowicz, MM ;

Lewis, MD ;

Yan, PS ;

Huang, THM ;

Weinmann, AS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (17) :11992-12000

[6] Regulation of the cyclin-Dependent Kinase Inhibitor p57Kip2 Expression by p63 [J].

Beretta, C ;

Chiarelli, A ;

Testoni, B ;

Mantovani, R ;

Guerrini, L .

CELL CYCLE, 2005, 4 (11) :1625-1631

[7] Canonical Notch signaling functions as a commitment switch in the epidermal lineage [J].

Blanpain, Cedric ;

Lowry, William E. ;

Pasolli, H. Amalia ;

Fuchs, Elaine .

GENES & DEVELOPMENT, 2006, 20 (21) :3022-3035

[8] The p63 gene in EEC and other syndromes [J].

Brunner, HG ;

Hamel, BCJ ;

van Bokhoven, H .

JOURNAL OF MEDICAL GENETICS, 2002, 39 (06) :377-381

[9] INDUCTION OF THE GROWTH INHIBITOR IGF-BINDING PROTEIN-3 BY P53 [J].

BUCKBINDER, L ;

TALBOTT, R ;

VELASCOMIGUEL, S ;

TAKENAKA, I ;

FAHA, B ;

SEIZINGER, BR ;

KLEY, N .

NATURE, 1995, 377 (6550) :646-649

[10] Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice [J].

Candi, E. ;

Rufini, A. ;

Terrinoni, A. ;

Dinsdale, D. ;

Ranalli, M. ;

Paradisi, A. ;

De Laurenzi, V. ;

Spagnoli, L. G. ;

Catani, M. V. ;

Ramadan, S. ;

Knight, R. A. ;

Melino, G. .

CELL DEATH AND DIFFERENTIATION, 2006, 13 (06) :1037-1047

← 1 2 3 4 5 6 7 →