Redundant early and overlapping larval roles of Xsox17 subgroup genes in Xenopus endoderm development

被引:24
作者
Clements, D [1 ]
Cameleyre, I [1 ]
Woodland, HR [1 ]
机构
[1] Univ Warwick, Dept Sci Biol, Coventry CV4 7AL, W Midlands, England
关键词
Xsox17; endoderm; gut; Xenopus; morpholino;
D O I
10.1016/S0925-4773(02)00450-1
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have used antisense morpholino oligos to establish the developmental roles of three Xsox17 proteins in Xenopus development (Xsox17alpha(1), alpha(2) and beta). We show that their synthesis can be inhibited with modest amounts of oligo. The inhibition of each individually produces defects in late midgut development. Loss of activity of the Xsox17alpha proteins additionally inhibits hindgut formation, and inhibiting Xsox17alpha I disrupts foregut development with variable penetrance. When all Xsox17 activity is inhibited cell movements are halted during late gastrulation and the transcription of several endodermally expressed genes is reduced. Thus the Xsox17 proteins have redundant roles in early development of the endoderm and partly distinct roles during later organogenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:337 / 348
页数:12
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