Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival

被引：211

作者：

Hock, H

Meade, E

Medeiros, S

Schindler, JW

Valk, PJM

Fujiwara, Y

Orkin, SH ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Childrens Hosp,Div Hematol Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[4] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

GENES & DEVELOPMENT | 2004年 / 18卷 / 19期

关键词：

Ets; hematopoietic stem cell; megakarvocyte; Cre/loxP; Tel/Etv6;

D O I：

10.1101/gad.1239604

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we report that the Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocations in leukemia, is a selective regulator of HSC survival. Following inactivation of Tel/Etv6, HSCs are lost in the adult bone marrow but their progeny are unaffected and transiently sustain blood formation. Accordingly, absence of Tel/Etv6 after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes. Thus, we establish Tel/Etv6 as a selective and essential regulator of postembryonic HSCs.

引用

页码：2336 / 2341

页数：6

共 31 条

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