A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent acquisition of sexually transmitted diseases

被引:69
作者
Schwebke, Jane R. [1 ]
Desmond, Renee [1 ]
机构
[1] Univ Alabama, Sch Med, Dept Med, Birmingham, AL 35294 USA
关键词
bacterial vaginosis; chlamydia; metronidazole gel; sexually transmitted disease (STD);
D O I
10.1016/j.ajog.2007.02.048
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Women with asymptomatic bacterial vaginitis were assigned randomly to observation or treatment and prophylaxis with intravaginal metronidazole gel to determine whether treatment decreases the incidence of sexually transmitted diseases.
引用
收藏
页码:517 / 519
页数:3
相关论文
共 26 条
[1]  
Amsel R., Totten P.A., Spiegel C.A., Chen K.C.S., Eschenbach D., Holmes K.K., Non-specific vaginitis: diagnostic and microbial and epidemiological associations, Am J Med, 74, pp. 14-22, (1983)
[2]  
Cohen M.S., Sexually transmitted diseases enhance HIV transmission: no longer a hypothesis, Lancet, 351, pp. 5-7, (1998)
[3]  
Cherpes T., Meyn L., Krohn M.A., Lurie J., Hillier S.L., Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis, Clin Infect Dis, 37, pp. 319-325, (2003)
[4]  
Watts D., Fazarri M., Minkoff H., Et al., Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1- infected and high-risk HIV-1-uninfected women, J Infect Dis, 191, pp. 1129-1139, (2005)
[5]  
Hillier S., The vaginal microbial ecosystem and resistance to HIV, AIDS, 14, pp. 17-21, (1998)
[6]  
Klebanoff S.J., Hillier S.L., Eschenbach D.A., Waltersdorph A.M., Control of the microbial flora of the vagina by H<sub>2</sub>O<sub>2</sub> -generating lactobacilli, J Infect Dis, 164, pp. 94-100, (1991)
[7]  
Grosskurth H., Mosha F., Todd J., Et al., Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial, Lancet, 346, pp. 530-536, (1995)
[8]  
Wawer M., Sewankambo N., Serwadda D., Quinn T., Paxton L., Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomized community trial, Lancet, 353, pp. 525-535, (1999)
[9]  
Sexually transmitted diseases treatment guidelines, MMWR Recomm Rep, 55, pp. 49-56, (2006)
[10]  
Sobel J., Ferris D., Schwebke J., Et al., Suppressive maintenance antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis, Am J Obstet Gynecol, 194, pp. 1283-1289, (2006)