One-pot synthesis of dihydropyrimidinones using iodotrimethylsilane. Facile and new improved protocol for the Biginelli reaction at room temperature

被引：112

作者：

Sabitha, G ^{[1
]}

Reddy, GSKK ^{[1
]}

Reddy, CS ^{[1
]}

Yadav, JS ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNLETT | 2003年 / 06期

关键词：

Biginelli reaction; dihydropyrimidinones; iodotrimethyl silane; one-pot condensation; room temperature;

D O I：

10.1055/s-2003-38734

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel one pot condensation of an aldehyde, beta-ketoester and urea has been performed using TMSI in acetonitrill for the first time at room temperature affording dihydropyrimidinones in excellent yields.

引用

页码：858 / 860

页数：3

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