The genetics of cell death:: Approaches, insights and opportunities in Drosophila

被引：74

作者：

Hay, BA

Huh, JR

Guo, M

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Dept Neurol, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg1491

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cell death is ubiquitous in metazoans and involves the action of an evolutionarily conserved process known as programmed cell death or apoptosis. In Drosophila melanogaster, it is now uniquely possible to screen for genes that determine the fate - life or death - of any cell or population of cells during development and in the adult. This review describes these genetic approaches and the key insights into cell-death mechanisms that have been obtained, as well as the outstanding questions that these techniques can help to answer.

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收藏

页码：911 / 922

页数：12

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