Murine strain differences in airway inflammation caused by diesel exhaust particles

被引:75
作者
Miyabara, Y
Yanagisawa, R
Shimojo, N
Takano, H
Lim, HB
Ichinose, T
Sagai, M
机构
[1] Natl Inst Environm Studies, Res Team Hlth Effects Air Pollutants, Tsukuba, Ibaraki 305, Japan
[2] Univ Tsukuba, Sch Environm Sci, Tsukuba, Ibaraki 305, Japan
[3] Univ Tsukuba, Sch Med, Tsukuba, Ibaraki 305, Japan
关键词
airway hyperresponsiveness; allergic airway inflammation; cytokine; diesel exhaust particles; immunoglobulin G1;
D O I
10.1183/09031936.98.11020291
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
To elucidate whether immunoglobulin (Ig) E or IgG are involved in the murine asthma model, we compared the pathogenic features of mice that were high IgG responders (C3H/He) with mice that were high IgE responders (BALB/c) after intratracheal instillation of diesel exhaust particles (DEP) and ovalbumin sensitization. Both mouse strains received DEP intratracheally once a week for 5 weeks, After the second injection of DEP, ovalbumin and aluminium hydroxide mere injected intraperitoneally. After the last DEP administration, the mice were challenged by exposure to an aerosol of ovalbumin. DEP caused increased IgG1 production and airway hyperresponsiveness after ovalbumin sensitization in C3H/He mice, although IgE production did not change in either strain, Furthermore, in C3H/He mice, the number of eosinophils and goblet cells in the bronchial epithelium, and the expression of interleukin-5 and interleukin-2 were increased by DEP and ovalbumin treatments. In contrast, the pathogenic changes in BALB/c mice were weak, even though the same protocol was used. In conclusion, murine strain differences in response to air pollutants and allergens seem to be related to antigen-specific immunoglobulin G1 production and cytokine expression in the lungs.
引用
收藏
页码:291 / 298
页数:8
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