Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana

被引：69

作者：

Chang, YC

Hsieh, PW

Chang, FR

Wu, RR

Liaw, CC

Lee, KH

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Kao Yuan Inst Technol, Dept Chem Engn, Kaohsiung, Taiwan

[3] Natl Cheng Kung Univ, Tainan Reg Instrument Ctr, Tainan 70101, Taiwan

[4] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC USA

来源：

PLANTA MEDICA | 2003年 / 69卷 / 02期

关键词：

Argemone mexicana; Papaveraceae; argemexicaine A; argemexicaine B; protopine; benzo[c]phenanthridine; (+/-)-6-acetonyldihydrochelerythrine; anti-HIV activity;

D O I：

10.1055/s-2003-37710

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new protopine-type alkaloids, argemexicame A (1) and argemexicame B (2), along with thirteen known alkaloids, were isolated from MeOH extracts of Formosan Argemone mexicana L. (Papaveraceae). Physical and spectral analyses, particularly IR and thermo-modulated 1D and 2D NMR, were used to determine the transannular conformations of the isolated protopine-type alkaloids. The known benzo[c]phenanthridine (+/-)-6-acetonyldihydrochelerythrine (5) exhibited significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 mug/mL and 14.6, respectively.

引用

页码：148 / 152

页数：5

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