Acaricidal activity of tonka bean extracts. Synthesis and structure - Activity relationships of bioactive derivatives

被引：33

作者：

Gleye, C

Lewin, G

Laurens, A ^{[1
]}

Jullian, JC

Loiseau, P

Bories, C

Hoequemiller, R

机构：

[1] Univ Paris 11, Fac Pharm, Lab Pharmacognosie, UMR 8076 CNRS BioCIS, F-92296 Chatenay Malabry, France

[2] Univ Paris 11, Fac Pharm, UMR 8076 CNRS BioCIS, Lab Chimiotherapie Antiparasitaire, F-92296 Chatenay Malabry, France

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 05期

关键词：

D O I：

10.1021/np020563j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The acaricidal effects of tonka bean, Dipterix odorata, extracts were investigated on Dermatophagoides pteronyssinus, the European house dust mite, and compared with benzyl benzoate as a standard acaricidal compound. A cyclohexane extract was the most effective, with an EC50 = 0.075 g/m(2) after a 24 h period, as compared with benzyl benzoate (0.025 g/m(2)). Bioassay-guided fractionation of this extract led to the isolation of coumarin (1). Pharmacomodulation of this compound led us to test 20 analogues (2-21), which were either synthesized or purchased.

引用

页码：690 / 692

页数：3

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