Cyanide-sensitive fluorescent probes

被引：114

作者：

Badugu, R

Lakowicz, JR

Geddes, CD

机构：

[1] Univ Maryland, Sch Med, Ctr Fluorescence Spect, Dept Biochem & Mol Biol,Med Biotechnol Ctr, Baltimore, MD 21201 USA

[2] Univ Maryland, Inst Biotechnol, Inst Fluroescence, Ctr Med Biotechnol, Baltimore, MD 21201 USA

[3] Univ Maryland, Ctr Fluorescence Spect, Inst Fluroescence, Ctr Med Biotechnol, Baltimore, MD 21201 USA

来源：

DYES AND PIGMENTS | 2005年 / 64卷 / 01期

关键词：

cyanide sensing; boronic acid; ratiometric fluorescence sensing; colorimetric response; poison; physiological safeguard;

D O I：

10.1016/j.dyepig.2004.04.002

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We characterize the response of several boronic acid containing fluorophores, which are widely used for sugar determination, towards aqueous cyanide. In two recent reports we have shown that boronic acid containing fluorophores can be used to sense aqueous cyanide through physiological safeguard levels. In this report we show that our new sensing mechanism is not just specific to our recently reported probes, but is indeed generic to the boronic acid moiety itself. Subsequently a wide range of cyanidesensitive probes can now be realized, offering several modalities for fluorescence based cyanide sensing such as: intensity, lifetime, ratiometric, polarization and modulation fluorescence sensing. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：49 / 55

页数：7

共 30 条

[1] Excitation and emission wavelength ratiometric cyanide-sensitive probes for physiological sensing
Badugu, R
Lakowicz, JR
Geddes, CD
[J]. ANALYTICAL BIOCHEMISTRY, 2004, 327 (01) : 82 - 90
[2] A wavelength-ratiometric pH sensitive probe based on the boronic acid moiety and suppressed sugar response
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Lakowicz, JR
Geddes, CD
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Lakowicz, JR
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[4] BADUGU R, UNPUB CYANIDE SENSIN
[5] BADUGU R, IN PRESS SENSORS A B
[6] BADUGU R, UNPUB FLUORESCENCE I
[7] Wavelength-ratiometric probes for saccharides based on donor-acceptor diphenylpolyenes
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[8] Spectral properties of fluorophores combining the boronic acid group with electron donor or withdrawing groups. Implication in the development of fluorescence probes for saccharides
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[J]. JOURNAL OF PHYSICAL CHEMISTRY A, 2001, 105 (28) : 6834 - 6840
[9] New color chemosensors for monosaccharides based on Azo dyes
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Lakowicz, JR
[J]. ORGANIC LETTERS, 2001, 3 (24) : 3891 - 3893
[10] Spectroscopic and photophysical characterization of fluorescent chemosensors for monosaccharides based on N-phenylboronic acid derivatives of 1,8-naphthalimide
DiCesare, N
Adhikari, DP
Heynekamp, JJ
Heagy, MD
Lakowicz, JR
[J]. JOURNAL OF FLUORESCENCE, 2002, 12 (02) : 147 - 154

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