In vitro activity of fosfomycin trometamol against pathogens from urinary tract infections: A Spanish multicenter study

被引:20
作者
Garcia-Rodriguez, JA [1 ]
Martin, IT [1 ]
Baquero, F [1 ]
Cisterna, R [1 ]
Gobernado, M [1 ]
Linares, F [1 ]
Martin-Luengo, F [1 ]
Piedrola, G [1 ]
机构
[1] Univ Hosp, Dept Microbiol & Parasitol, Salamanca 37007, Spain
关键词
fosfomycin trometamol; urinary tract infections (UTIs);
D O I
10.1179/joc.1997.9.6.394
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The in-vitro susceptibilities of a total of 1371 urinary tract pathogens to fosfomycin trometamol were determined. According to the NCCLS breakpoints, Enterobacteriaceae and Gram-positive microorganisms were, in general, very sensitive to this antimicrobial. More than 90.0% of the Escherichia coli and Citrobacter spp. and more than 70.0% of the Klebsiella pneumoniae, K. oxytoca, Enterobacter spp., Proteus mirabilis, Staphylococcus aureus, coagulase-negative staphylococci and Enterococcus spp. strains tested were susceptible to fosfomycin trometamol. However, Pseudomonas aeruginosa and Acinetobacter spp. strains were more resistant. in general, recent clinical isolates From urinary tract infections (UTIs) in both community and hospital were also very sensitive (>80.0%) to fosfomycin, its activity being higher than that of the rest of the antimicrobials commonly used for therapy of uncomplicated UTIs. More than 75.0% of the most frequently isolated pathogens from UTIs, except for P. aeruginosa (31.8%) and Acinetobacter spp. (11.1%), were susceptible to fosfomycin trometamol. The results obtained in this study, together with the infrequency of side effects and its pharmacokinetic properties, indicate that fosfomycin trometamol may be a useful alternative for single-dose therapy of uncomplicated UTIs.
引用
收藏
页码:394 / 402
页数:9
相关论文
共 16 条
[1]   INTERNATIONAL COLLABORATIVE STUDY ON STANDARDIZATION OF BACTERIAL SENSITIVITY TO FOSFOMYCIN [J].
ANDREWS, JM ;
BAQUERO, F ;
BELTRAN, JM ;
CANTON, E ;
CROKAERT, F ;
GOBERNADO, M ;
GOMEZLUS, R ;
LOZA, E ;
NAVARRO, M ;
OLAY, T ;
RODRIGUEZ, A ;
VICENTE, MV ;
WISE, R ;
YOURASSOWSKY, E .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1983, 12 (04) :357-361
[2]  
[Anonymous], M7A2 NCCLS
[3]   INVITRO SUSCEPTIBILITY TESTING PROCEDURES FOR FOSFOMYCIN TROMETHAMINE [J].
BARRY, AL ;
FUCHS, PC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (06) :1235-1238
[4]  
BERGAN T, 1990, INFECTION S2, V18, pS75
[5]   FOSFOMYCIN TROMETAMOL IN A SINGLE DOSE VERSUS NORFLOXACIN FOR 7 DAYS IN THE TREATMENT OF UNCOMPLICATED URINARY INFECTIONS IN GENERAL-PRACTICE [J].
BOEREMA, JBJ ;
WILLEMS, FTC .
INFECTION, 1990, 18 :S80-S88
[6]  
CORBUSIER A, 1988, P185
[7]  
Ferrari V., 1981, CHEMIOTER ANTIMICROB, V4, P59
[8]   ANTI-MICROBIAL ACTIVITY OF FOSFOMYCIN INVITRO [J].
FORSGREN, A ;
WALDER, M .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1983, 11 (05) :467-471
[9]  
GREENWOOD D, 1987, EUR UROL, V13, P69
[10]  
KING A, 1988, P242