Stepwise specification of lymphocyte developmental lineages

被引：72

作者：

Rothenberg, EV ^{[1
]}

机构：

[1] CALTECH, Div Biol 156 29, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0959-437X(00)00098-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-lineage specification and commitment now illuminate this process.

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页码：370 / 379

页数：10

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