Synthesis of nir-sensitive Au-Au2S nanocolloids for drug delivery

被引：54

作者：

Ren, L

Chow, GM

机构：

[1] Natl Univ Singapore, Singapore MIT Alliance, Singapore 119260, Singapore

[2] Natl Univ Singapore, Dept Mat Sci, Singapore 119260, Singapore

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2003年 / 23卷 / 1-2期

关键词：

drug delivery; near-infrared; Au-Au2S; nanoparticles; cis-platin;

D O I：

10.1016/S0928-4931(02)00247-3

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Near IR (NIR) sensitive Au-Au2S nanocolloids were prepared by mixing HAuCl4 and Na2S in aqueous solutions. An anti-tumor drug, cis-platin, was adsorbed onto Au-Au2S nanoparticle surface via the 11-mercaptoundecanoic acid (MUA) layers. The results show that the degree of adsorption of cis-platin onto Au-Au2S nanoparticles was controlled by the solution pH value, and the drug release was sensitive to near-infrared irradiation. The cis-platin-loaded Au-Au2S nanocolloids can be potentially applied as NIR activated drug delivery carrier. (C) 2002 Elsevier Science B.V All rights reserved.

引用

页码：113 / 116

页数：4

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