Functionalization of PAMAM dendrimers with nitronyl nitroxide radicals as models for the outer-sphere relaxation in dentritic potential MRI contrast agents

被引：44

作者：

Francese, G

Dunand, FA

Loosli, C

Merbach, AE

Decurtins, S

机构：

[1] Cerbios Pharma SA, R&D Sapec Div, CH-6917 Barbengo, Switzerland

[2] Ecole Polytech Fed Lausanne, Inst Chim Mol & Biol, CH-1015 Lausanne, Switzerland

[3] Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2003年 / 41卷 / 02期

关键词：

NMR; H-1; NMRD; EPR; MRI; PAMAM dendrimers; free radicals;

D O I：

10.1002/mrc.1151

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

PAMAM dendrimers functionalized with nitronyl nitroxide radicals were characterized. Quantitative determination of substitution with radicals was performed using EPR and electrochemical methods. The study of the H-1 NMR relaxation of the surrounding water showed how the outer-sphere contribution to the relaxivity may be limited by the presence of the dendrimer core. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：81 / 83

页数：3

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