Discovery of pyrano[3,4-b]indoles as potent and selective HCVNS5B polymerase inhibitors

被引：96

作者：

Gopalsamy, A ^{[1
]}

Lim, K

Ciszewski, G

Park, K

Ellingboe, JW

Bloom, J

Insaf, S

Upeslacis, J

Mansour, TS

Krislinamurthy, G

Damarla, M

Pyatski, Y

Ho, D

Howe, AYM

Orlowski, M

Feld, B

O'Connell, J

机构：

[1] Wyeth Ayerst Res, Chem & Screening Sci & Infect Dis, Pearl River, NY 10965 USA

[2] Princeton Univ, Princeton, NJ 08544 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 26期

关键词：

D O I：

10.1021/jm0401255

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano-[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.

引用

页码：6603 / 6608

页数：6

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