Changing the end: antigenic variation orchestrated at the telomeres of African trypanosomes

被引：50

作者：

Rudenko, G ^{[1
]}

Cross, M ^{[1
]}

Borst, P ^{[1
]}

机构：

[1] Netherlands Canc Inst, Dept Mol Biol, NL-1066 CX Amsterdam, Netherlands

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 03期

关键词：

D O I：

10.1016/S0966-842X(97)01200-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

African trypanosomes express the gene encoding their variant surface glycoprotein (VSG) surface coat from one of many telomeric expression sites. This genomic location at chromosome ends not only allows easy exchange of VSG gene cassettes using various mechanisms of DNA recombination but also appears to play a role in VSG gene expression site control.

引用

页码：113 / 117

页数：5

共 43 条

[1] A MONOCISTRONIC TRANSCRIPT FOR A TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN [J].

ALARCON, CM ;

SON, HJ ;

HALL, T ;

DONELSON, JE .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (08) :5579-5591

[2] STABLE EXPRESSION OF 2 VARIABLE SURFACE GLYCOPROTEINS BY CLONED TRYPANOSOMA-EQUIPERDUM [J].

BALTZ, T ;

GIROUD, C ;

BALTZ, D ;

ROTH, C ;

RAIBAUD, A ;

EISEN, H .

NATURE, 1986, 319 (6054) :602-604

[3] The relative significance of mechanisms of antigenic variation in African trypanosomes [J].

Barry, JD .

PARASITOLOGY TODAY, 1997, 13 (06) :212-218

[4] The PARP promoter of Trypanosoma brucei is developmentally regulated in a chromosomal context [J].

Biebinger, S ;

Rettenmaier, S ;

Flaspohler, J ;

Hartmann, C ;

PenaDiaz, J ;

Wirtz, LE ;

Hotz, HR ;

Barry, JD ;

Clayton, C .

NUCLEIC ACIDS RESEARCH, 1996, 24 (07) :1202-1211

[5]

Borst P, 1996, ARCH MED RES, V27, P379

[6] ANTIGENIC VARIATION IN AFRICAN TRYPANOSOMES [J].

BORST, P ;

RUDENKO, G .

SCIENCE, 1994, 264 (5167) :1872-1873

[7] RELEASE OF THE VARIANT SURFACE GLYCOPROTEIN DURING DIFFERENTIATION OF BLOOD-STREAM TO PROCYCLIC FORMS OF TRYPANOSOMA-BRUCEI [J].

BULOW, R ;

NONNENGASSER, C ;

OVERATH, P .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 32 (01) :85-92

[8] 2 SIMULTANEOUSLY ACTIVE VSG GENE-TRANSCRIPTION UNITS IN A SINGLE TRYPANOSOMA BRUCEI VARIANT [J].

CORNELISSEN, AWCA ;

JOHNSON, PJ ;

KOOTER, JM ;

VANDERPLOEG, LHT ;

BORST, P .

CELL, 1985, 41 (03) :825-832

[9] Antigenic variation in trypanosomes: Secrets surface slowly [J].

Cross, GAM .

BIOESSAYS, 1996, 18 (04) :283-291

[10] Manipulation of the vsg co-transposed region increases expression-site switching in Trypanosoma brucei [J].

Davies, KP ;

Carruthers, VB ;

Cross, GAM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 86 (02) :163-177

← 1 2 3 4 5 →