Changing the end: antigenic variation orchestrated at the telomeres of African trypanosomes

被引:50
作者
Rudenko, G [1 ]
Cross, M [1 ]
Borst, P [1 ]
机构
[1] Netherlands Canc Inst, Dept Mol Biol, NL-1066 CX Amsterdam, Netherlands
关键词
D O I
10.1016/S0966-842X(97)01200-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
African trypanosomes express the gene encoding their variant surface glycoprotein (VSG) surface coat from one of many telomeric expression sites. This genomic location at chromosome ends not only allows easy exchange of VSG gene cassettes using various mechanisms of DNA recombination but also appears to play a role in VSG gene expression site control.
引用
收藏
页码:113 / 117
页数:5
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