DNA interactions of two clinical camptothecin drugs stabilize their active lactone forms

被引：74

作者：

Yang, DZ

Strode, JT

Spielmann, HP

Wang, AHJ

Burke, TG ^{[1
]}

机构：

[1] Univ Kentucky, Coll Pharm, Div Med Chem & Pharmaceut, Lexington, KY 40506 USA

[2] Univ Kentucky, Coll Med, Dept Biochem, Lexington, KY 40506 USA

[3] Univ Kentucky, Coll Arts & Sci, Dept Chem, Markey Canc Ctr, Lexington, KY 40506 USA

[4] Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 120卷 / 12期

关键词：

D O I：

10.1021/ja973433j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：2979 / 2980

页数：2

共 19 条

[1] STRUCTURAL MODIFICATIONS OF CAMPTOTHECIN AND EFFECTS ON TOPOISOMERASE-I INHIBITION [J].

CROW, RT ;

CROTHERS, DM .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (22) :4160-4164

[2] A KINETIC AND MECHANISTIC STUDY OF THE HYDROLYSIS OF CAMPTOTHECIN AND SOME ANALOGS [J].

FASSBERG, J ;

STELLA, VJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1992, 81 (07) :676-684

[3] INTERACTIONS OF ANTITUMOR DRUGS WITH NATURAL DNA - H-1-NMR STUDY OF BINDING MODE AND KINETICS [J].

FEIGON, J ;

DENNY, WA ;

LEUPIN, W ;

KEARNS, DR .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (04) :450-465

[4] Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form [J].

Henningfeld, KA ;

Arslan, T ;

Hecht, SM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (47) :11701-11714

[5] MODIFICATION OF THE HYDROXY LACTONE RING OF CAMPTOTHECIN - INHIBITION OF MAMMALIAN TOPOISOMERASE-I AND BIOLOGICAL-ACTIVITY [J].

HERTZBERG, RP ;

CARANFA, MJ ;

HOLDEN, KG ;

JAKAS, DR ;

GALLAGHER, G ;

MATTERN, MR ;

MONG, SM ;

BARTUS, JO ;

JOHNSON, RK ;

KINGSBURY, WD .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (03) :715-720

[6] ON THE MECHANISM OF TOPOISOMERASE-I INHIBITION BY CAMPTOTHECIN - EVIDENCE FOR BINDING TO AN ENZYME DNA COMPLEX [J].

HERTZBERG, RP ;

CARANFA, MJ ;

HECHT, SM .

BIOCHEMISTRY, 1989, 28 (11) :4629-4638

[7]

JAXEL C, 1989, CANCER RES, V49, P1465

[8]

JAXEL C, 1989, CANCER RES, V49, P5077

[9] Mechanism of action of camptothecin [J].

Liu, LF ;

Duann, P ;

Lin, CT ;

DArpa, P ;

Wu, JX .

CAMPTOTHECINS: FROM DISCOVERY TO THE PATIENT, 1996, 803 :44-49

[10] REDUCED ALBUMIN-BINDING PROMOTES THE STABILITY AND ACTIVITY OF TOPOTECAN IN HUMAN BLOOD [J].

MI, ZH ;

MALAK, H ;

BURKE, TG .

BIOCHEMISTRY, 1995, 34 (42) :13722-13728

← 1 2 →