Pathogenesis of osteoporosis

被引：81

作者：

Raisz, LG

Rodan, GA

机构：

[1] Univ Connecticut, Ctr Hlth, Div Endocrinol & Metab, Farmington, CT 06030 USA

[2] Merck Res Labs, Dept Bone Biol & Osteoporosis Res, West Point, PA 19486 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2003年 / 32卷 / 01期

关键词：

D O I：

10.1016/S0889-8529(02)00055-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review summarizes some of the key mechanisms that may contribute to low bone mass and fragility and provides references to some of the recently identified pathways. The specific pathogenetic mechanisms in osteoporosis are poorly understood. Multiple pathways can lead to bone fragility, hence there are likely to be many different ways that osteoporosis can develop. We focus on the systemic and local factors that regulate bone remodeling and their potential roles in the pathogenesis of osteoporosis.

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页码：15 / +

页数：11

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