Heparin and heparan sulfate: biosynthesis, structure and function

被引：271

作者：

Sasisekharan, R ^{[1
]}

Venkataraman, G

机构：

[1] MIT, Ctr Biomed Engn, Cambridge, MA 02139 USA

[2] MIT, Div Bioengn & Environm Hlth, Cambridge, MA 02139 USA

[3] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 06期

关键词：

D O I：

10.1016/S1367-5931(00)00145-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heparin and heparan sulfate glycosaminoglycans are acidic complex polysaccharides found on the cell surface and in the extracellular matrix. Recent progress has uncovered a virtual explosion of important roles of these biopolymers in fundamental biological processes. Advances in the understanding of biosynthesis and structure and the development of novel analytical methods for composition and sequence analysis have provided remarkable insights into structure/function relationships of these complex and once elusive polysaccharides.

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收藏

页码：626 / 631

页数：6

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[1] CONTROVERSIAL GLYCOSAMINO-GLYCAN CONFORMATIONS [J].

CASU, B ;

CHOAY, J ;

FERRO, DR ;

GATTI, G ;

JACQUINET, JC ;

PETITOU, M ;

PROVASOLI, A ;

RAGAZZI, M ;

SINAY, P ;

TORRI, G .

NATURE, 1986, 322 (6076) :215-216

[2] Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate [J].

Chen, YP ;

Maguire, T ;

Hileman, RE ;

Fromm, JR ;

Esko, JD ;

Linhardt, RJ ;

Marks, RM .

NATURE MEDICINE, 1997, 3 (08) :866-871

[3]

Conrad H.E., 1998, HEPARIN BINDING PROT

[4] Structure of a heparin-linked biologically active dimer of fibroblast growth factor [J].

DiGabriele, AD ;

Lax, I ;

Chen, DI ;

Svahn, CM ;

Jaye, M ;

Schlessinger, J ;

Hendrickson, WA .

NATURE, 1998, 393 (6687) :812-817

[5] Pyranose ring flexibility. Mapping of physical data for iduronate in continuous conformational space [J].

Ernst, S ;

Venkataraman, G ;

Sasisekharan, V ;

Langer, R ;

Cooney, CL ;

Sasisekharan, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (09) :2099-2107

[6] Direct evidence for a predominantly exolytic processive mechanism for depolymerization of heparin-like glycosaminoglycans by heparinase I [J].

Ernst, S ;

Rhomberg, AJ ;

Biemann, K ;

Sasisekharan, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) :4182-4187

[7] Diversity does make a difference: fibroblast growth factor-heparin interactions [J].

Faham, S ;

Linhardt, RJ ;

Rees, DC .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1998, 8 (05) :578-586

[8] Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme [J].

Forsberg, E ;

Pejler, G ;

Ringvall, M ;

Lunderius, C ;

Tomasini-Johansson, B ;

Kusche-Gullberg, M ;

Eriksson, I ;

Ledin, J ;

Hellman, L ;

Kjellén, L .

NATURE, 1999, 400 (6746) :773-776

[9] The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex [J].

Fry, EE ;

Lea, SM ;

Jackson, T ;

Newman, JWI ;

Ellard, FM ;

Blakemore, WE ;

Abu-Ghazaleh, R ;

Samuel, A ;

King, AMQ ;

Stuart, DI .

EMBO JOURNAL, 1999, 18 (03) :543-554

[10] Diversity and functions of glycosaminoglycan sulfotransferases [J].

Habuchi, O .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2000, 1474 (02) :115-127

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