Does massively parallel DNA resequencing signify the end of histopathology as we know it?

被引：38

作者：

Aparicio, Samuel A. J. R. ^{[1
,2
]}

Huntsman, David G. ^{[1
,2
]}

机构：

[1] BC Canc Agcy, Ctr Translat & Appl Genom, Vancouver, BC V5Z 1L3, Canada

[2] Univ British Columbia, Dept Pathol, Vancouver, BC V6T 2B5, Canada

来源：

JOURNAL OF PATHOLOGY | 2010年 / 220卷 / 02期

关键词：

DNA sequencing; mutational heterogeneity; cancer genome; transcriptome; tissue sampling; mutational landscape; tumour evolution; SIGNALING PATHWAYS; GENOMIC ANALYSIS; SHORT-READ; CANCER; DISCOVERY; SEQUENCE; DIAGNOSIS; VARIANTS; MUTATION;

D O I：

10.1002/path.2636

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Next-generation DNA sequencing devices have revolutionized cancer genomics by bringing whole genome resequencing of patients' tumours within practical and economic reach. We present an overview of the techniques involved and review early results from the resequencing of cancer genomes. The possible impacts of whole-genome and trancriptome resequencing in clinical cancer research and the practice of pathology are discussed. Copyright (C) 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：307 / 315

页数：9

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