Fission yeast synaptobrevin is involved in cytokinesis and cell elongation

被引：40

作者：

Edamatsu, M ^{[1
]}

Toyoshima, YY ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 301卷 / 03期

关键词：

Schizosaccharomyces pombe; fission yeast; cytokinesis; membrane trafficking; SNARE; synaptobrevin;

D O I：

10.1016/S0006-291X(03)00017-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synaptobrevin is a vesicle-associated membrane protein playing an essential role in regulated vesicle transport. In this study, we characterized Syb1, synaptobrevin of Schizosaccharomyces pombe. Syb1 was located on various sizes of vesicle-like structures in the cytoplasm and enriched in the medial region and cell ends. Transport of Syb1 to the medial region was mainly dependent on F-actin and Myo52/Myo4. Syb1 is essential for cell viability and most of the syb1-null cells showed a round or short cylindrical form. These results suggest that Syb1 is involved in membrane trafficking of cytokinesis and cell elongation. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：641 / 645

页数：5

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