The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS)

被引：12

作者：

Chernyshev, Anatoly

Fleischmann, Todd

Koehn, Eric M.

Lesley, Scott A.

Kohen, Amnon ^{[1
]}

机构：

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

[2] Novartis Res Fdn, Joint Ctr Struct Genom, Genom Inst, San Diego, CA 92121 USA

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 27期

关键词：

D O I：

10.1039/b700977a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New findings lead to a revised understanding of the substrates' binding order, the role of the substrate as an activator, and the observed lag phase in the FDTS catalyzed reaction.

引用

页码：2861 / 2863

页数：3

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