Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells

被引：22

作者：

Ahn, KS

Kim, JH

Oh, SR

Ryu, SY

Lee, HK

机构：

[1] Korea Res Inst Biosci & Biotechnol, Immunomodulator Res Lab, Taejon 305600, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305606, South Korea

来源：

PLANTA MEDICA | 2000年 / 66卷 / 07期

关键词：

D O I：

10.1055/s-2000-8634

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). A cell-to-cell adhesion assay showed that 3,5-dihydroxy-4'-methoxystilbene and 2,3,4':5-tetrahydroxystilbene-2-O-beta-(D)-glucopyranoside as well as resveratrol blocked significantly TNF-alpha -inducing cell-cell adhesion between human umbilical vein endothelial cells (HUVEC) and THP-1 cells.

引用

页码：641 / 644

页数：4

共 17 条

[1] HUMAN-MEMORY T-CELLS EXPRESS INTERCELLULAR-ADHESION MOLECULE-1 WHICH CAN BE INCREASED BY INTERLEUKIN-2 AND INTERFERON-GAMMA [J].