Analysis of unknown compounds in azithromycin bulk samples with liquid chromatography coupled to ion trap mass spectrometry

被引：43

作者：

Debremaeker, D ^{[1
]}

Visky, D ^{[1
]}

Chepkwony, HK ^{[1
]}

Van Schepdael, A ^{[1
]}

Roets, E ^{[1
]}

Hoogmartens, J ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Fac Farm Wetenschappen, Lab Farm Chem Anal Geneesmiddelen, B-3000 Louvain, Belgium

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2003年 / 17卷 / 04期

关键词：

D O I：

10.1002/rcm.917

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A selective reversed-phase liquid chromatography/mass spectrometry (LC/MSn) method is described for the identification of azithromycin impurities and related substances in commercial azithromycin samples. Mass spectral data are acquired on an LCQ ion trap mass spectrometer equipped with an atmospheric pressure chemical ionization interface operated in positive ion mode. The LCQ provides on-line LC/MSn capability, making it ideally suited for identification purposes. In comparison with UV detection, this hyphenated technique provides as its main advantage efficient identification of novel substances without time-consuming isolation and purification procedures. Using this technique, six novel related substances detected in commercial azithromycin samples have been studied. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：342 / 350

页数：9

共 21 条

[1]

[Anonymous], ARCH ORG CHEM

[2] 23672 RP, A NEW MACROLIDE ANTIBIOTIC FROM STREPTOMYCES-CHRYSEUS - MASS-SPECTROMETRY STUDY AND X-RAY STRUCTURE DETERMINATION [J].