Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa

被引：37

作者：

Ko, JS

Rho, MC

Chung, MY

Song, HY

Kang, JS

Kim, K

Lee, HS

Kim, YK

机构：

[1] Korea Res Inst Biosci & Biotechnol, Lab Lipid Metab, Taejon 305600, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Taejon, South Korea

来源：

PLANTA MEDICA | 2002年 / 68卷 / 12期

关键词：

D O I：

10.1055/s-2002-36358

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4Z,7Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)quinolone (4). They showed a dose-dependent DGAT inhibition with IC50 values of 69.5 muM (1), 23.8 muM (2), 20.1 MM (3) and 13.5 mu (4).

引用

页码：1131 / 1133

页数：3

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