Genomics:: An in vitro toxicology point of view

被引：14

作者：

Corvi, R ^{[1
]}

机构：

[1] Commiss European Communities, Joint Res Ctr, Inst Hlth & Consumer Protect, ECVAM, I-21020 Ispra, VA, Italy

来源：

ATLA-ALTERNATIVES TO LABORATORY ANIMALS | 2002年 / 30卷

关键词：

gene expression; genomics; microarray; in vitro methods; toxicogenomics; toxicology;

D O I：

10.1177/026119290203002S21

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Genomics, and in particular its derived discipline, toxicogenomics, are rapidly developing technologies, which permit studies on the impact of chemicals and drugs on gene expression in particular biological systems. Enormous amounts of data will be provided in the context of mechanistic and predictive toxicology from the use of the DNA microarray approach for the simultaneous analysis of the expression pattern of multiple genes. The high-throughput requirement of these approaches necessitates in vitro cell culture systems. This article will give a short overview of the areas of ECVAM's research in which this technology will initially be applied.

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收藏

页码：129 / 131

页数：3

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