Controlled initiation of chromosomal replication in Escherichia coli requires functional Hda protein

被引：49

作者：

Camara, JE

Skarstad, K

Crooke, E

机构：

[1] Georgetown Univ, Med Ctr, Dept Biochem & Mol Biol, Washington, DC 20007 USA

[2] Norwegian Radium Hosp, Inst Canc Res, Dept Cell Biol, N-0310 Oslo, Norway

来源：

JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 10期

关键词：

D O I：

10.1128/JB.185.10.3244-3248.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Regulatory inactivation of DnaA helps ensure that the Escherichia coli chromosome is replicated only once per cell cycle, through accelerated hydrolysis of active replication initiator ATP-DnaA to inactive ADP-DnaA. Analysis of Deltahda strains revealed that the regulatory inactivation of DnaA component Hda is necessary for maintaining controlled initiation but not for cell growth or viability.

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收藏

页码：3244 / 3248

页数：5

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